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PMID: 19339403 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.

The American journal of clinical nutrition ·Vol. 89 ·No. 5 ·2009-05-00 ·Pages 1509S-1517S

Ordovas JM

Abstract

Genetic polymorphism in human populations is part of the evolutionary process that results from the interaction between the environment and the human genome. Recent changes in diet have upset this equilibrium, potentially influencing the risk of most common morbidities such as cardiovascular diseases, obesity, diabetes, and cancer. Reduction of these conditions is a major public health concern, and such a reduction could be achieved by improving our ability to detect disease predisposition early in life and by providing more personalized behavioral recommendations for successful primary prevention. In terms of cardiovascular diseases, polymorphisms at multiple genes have been associated with differential effects in terms of lipid metabolism; however, the connection with cardiovascular disease has been more elusive, and considerable heterogeneity exists among studies regarding the predictive value of genetic markers. This may be because of experimental limitations, the intrinsic complexity of the phenotypes, and the aforementioned interactions with environmental factors. The integration of genetic and environmental complexity into current and future research will drive the field toward the implementation of clinical tools aimed at providing dietary advice optimized for the individual's genome. This may imply that dietary changes are implemented early in life to gain maximum benefit. However, it is important to highlight that most reported studies have focused on adult populations and to extrapolate these findings to children and adolescents may not be justified until proper studies have been carried out in these populations and until the ethical and legal issues associated with this new field are adequately addressed.

MeSH Terms
Adult Apolipoproteins E/blood,deficiency Cardiovascular Diseases/blood,genetics,prevention & control Environment Feeding Behavior Female Genetic Variation Humans Lipids/blood Male Microsatellite Repeats/genetics PPAR gamma/genetics Primary Prevention Public Health
Chemicals
Apolipoproteins E Lipids PPAR gamma
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ordovas José M
Nutrition and Genomics Laboratory, USDA Human Nutrition Center on Aging, Tufts University, Boston, MA, USA. jose.ordovas@tufts.edu
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Article Info
Journal
The American journal of clinical nutrition
Abbr.
Am J Clin Nutr
ISSN
1938-3207
Published
2009-05-00
Epub
2009-00-01
Pages
1509S-1517S
Language
English
Region
United States
NLM ID
0376027
PMCID
PMC2677003
Subset
IM
Grants
NIA NIH HHS · 5P01AG023394-02 · United States
NIDDK NIH HHS · DK075030 · United States
NHLBI NIH HHS · HL54776 · United States
NHLBI NIH HHS · U01HL072524-04 · United States
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