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PMID: 19317561 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

A theory for viral capsid assembly around electrostatic cores.

The Journal of chemical physics ·Vol. 130 ·No. 11 ·2009-03-21 ·Pages 114902

Hagan MF

Abstract

We develop equilibrium and kinetic theories that describe the assembly of viral capsid proteins on a charged central core, as seen in recent experiments in which brome mosaic virus capsids assemble around nanoparticles functionalized with polyelectrolyte. We model interactions between capsid proteins and nanoparticle surfaces as the interaction of polyelectrolyte brushes with opposite charge using the nonlinear Poisson Boltzmann equation. The models predict that there is a threshold density of functionalized charge, above which capsids efficiently assemble around nanoparticles, and that light scatter intensity increases rapidly at early times without the lag phase characteristic of empty capsid assembly. These predictions are consistent with and enable interpretation of preliminary experimental data. However, the models predict a stronger dependence of nanoparticle incorporation efficiency on functionalized charge density than measured in experiments and do not completely capture a logarithmic growth phase seen in experimental light scatter. These discrepancies may suggest the presence of metastable disordered states in the experimental system. In addition to discussing future experiments for nanoparticle-capsid systems, we discuss broader implications for understanding assembly around charged cores such as nucleic acids.

MeSH Terms
Bromovirus/physiology Capsid Proteins/chemistry,metabolism Kinetics Models, Biological Nanoparticles/chemistry Static Electricity Surface Properties Thermodynamics Virus Assembly
Chemicals
Capsid Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hagan Michael F
Department of Physics, Brandeis University, Waltham, Massachusetts 02454, USA. hagan@brandeis.edu
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Article Info
Journal
The Journal of chemical physics
Abbr.
J Chem Phys
ISSN
1089-7690
Published
2009-03-21
Pages
114902
Language
English
Region
United States
NLM ID
0375360
PMCID
PMC2736580
Subset
IM
Grants
NIAID NIH HHS · R01 AI080791 · United States
NIAID NIH HHS · R01AI080791 · United States
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