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PMID: 19269192 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Surviving the crash: transitioning from effector to memory CD8+ T cell.

Seminars in immunology ·Vol. 21 ·No. 2 ·2009-04-00 ·Pages 92-8

D'Cruz LM, Rubinstein MP, Goldrath AW

Abstract

One outcome of infection is the formation of long-lived immunological memory, which provides durable protection from symptomatic re-infection. In response to infection or vaccination, T cells undergo dramatic proliferation and differentiate into effector T cells that mediate removal of the pathogen. Following pathogen clearance, the majority of effector cells die, restoring lymphocyte homeostasis. However, a small number of antigen-specific cells survive and seed the memory T cell population. Here, we focus on recent advances in identifying the key proteins and transcription factors that allow a portion of effector CD8(+) T cells to persist after contraction of the immune response, forming a memory cell population programmed for long-term self-renewal and survival. We also examine new findings addressing the role of environmental cues such as cytokines and co-stimulatory molecules in CD8(+) memory T cell formation and how the cell-extrinsic cues influence the molecular players of intracellular pathways important for memory formation.

MeSH Terms
Animals Apoptosis CD8-Positive T-Lymphocytes/immunology,metabolism,pathology Cell Differentiation Cytokines/genetics,immunology,metabolism Cytotoxicity, Immunologic DNA-Binding Proteins/immunology Humans Immunologic Memory Infections/immunology Inhibitor of Differentiation Protein 2/immunology Positive Regulatory Domain I-Binding Factor 1 Proto-Oncogene Proteins c-bcl-6 Repressor Proteins/immunology Signal Transduction T-Box Domain Proteins/immunology Transcriptional Activation/immunology
Chemicals
BCL6 protein, human Cytokines DNA-Binding Proteins EOMES protein, human ID2 protein, human Inhibitor of Differentiation Protein 2 Proto-Oncogene Proteins c-bcl-6 Repressor Proteins T-Box Domain Proteins T-box transcription factor TBX21 PRDM1 protein, human Positive Regulatory Domain I-Binding Factor 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
D'Cruz Louise M
University of California San Diego, Division of Biological Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0377, United States.
Rubinstein Mark P
Goldrath Ananda W
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Article Info
Journal
Seminars in immunology
Abbr.
Semin Immunol
ISSN
1044-5323
Published
2009-04-00
Epub
2009-00-06
Pages
92-8
Language
English
Region
England
NLM ID
9009458
PMCID
PMC2671236
Subset
IM
Grants
NIAID NIH HHS · R01 AI067545 · United States
NIAID NIH HHS · R01 AI067545-02 · United States
NIAID NIH HHS · R01 AI072117 · United States
NIAID NIH HHS · R01 AI072117-02 · United States
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