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PMID: 19186047 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Actin and endocytosis: mechanisms and phylogeny.

Current opinion in cell biology ·Vol. 21 ·No. 1 ·2009-02-00 ·Pages 20-7

Galletta BJ, Cooper JA

Abstract

The regulated assembly of actin filament networks is a crucial part of endocytosis, with crucial temporal and spatial relationships between proteins of the endocytic and actin assembly machinery. Of particular importance has been a wealth of studies in budding and fission yeast. Cell biology approaches, combined with molecular genetics, have begun to uncover the complexity of the regulation of actin dynamics during the endocytic process. In a wide range of organisms, clathrin-mediated endocytosis appears to be linked to Arp2/3-mediated actin assembly. The conservation of the components, across a wide range eukaryotic species, suggests that the partnership between endocytosis and actin may be evolutionarily ancient.

MeSH Terms
Actins/genetics,metabolism Animals Biological Evolution Endocytosis Eukaryotic Cells/metabolism Phylogeny
Chemicals
Actins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Galletta Brian J
Department of Cell Biology, Washington University Medical School, St Louis, MO, USA.
Cooper John A
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2009.01.006
Published
2009-02-00
Epub
2009-00-29
Pages
20-7
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2670849
Subset
IM
Grants
NIGMS NIH HHS · R01 GM047337 · United States
NIGMS NIH HHS · R01 GM038542 · United States
NIGMS NIH HHS · R01 GM038542-21 · United States
NIGMS NIH HHS · F32 GM077887 · United States
NIGMS NIH HHS · GM38542 · United States
NIGMS NIH HHS · R01 GM047337-15 · United States
NIGMS NIH HHS · GM077887 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2009.01.006 PMC Full Text View journal details
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