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PMID: 191840 Published · ppublish English Journal Article

Cleavage of Rous sarcoma viral polypeptide precursor into internal structural proteins in vitro involves viral protein p15.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 3 ·1977-03-00 ·Pages 911-5

von der Helm K

Abstract

The polypeptide precursor pr76 to the internal viral group specific (gs) antigen proteins of Rous sarcoma virus, synthesized in a cell-free system of ascites cells, has been processed in vitro into the viral proteins by purified viral protein p15 as well as by disrupted Rous sarcoma virus. Disrupted Rauscher murine leukemia virus does not stimulate the cleavage process in vitro. Autocatalytic cleavage of the polypeptide precursor pr76 or Rous sarcoma virus, which contains the peptide sequence of p15, is not observed.

MeSH Terms
Antigens, Viral Avian Sarcoma Viruses/metabolism Cell-Free System Protein Biosynthesis Protein Precursors/metabolism RNA, Viral/metabolism Viral Proteins/biosynthesis,metabolism
Chemicals
Antigens, Viral Protein Precursors RNA, Viral Viral Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
von der Helm K
References (23)
23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.3.911
Published
1977-03-00
Pages
911-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430528
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.3.911 PMC Full Text View journal details
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