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PMID: 19120478 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Viral sensors: diversity in pathogen recognition.

Immunological reviews ·Vol. 227 ·No. 1 ·2009-01-00 ·Pages 87-94

McCartney SA, Colonna M

Abstract

Innate sensors of viral infection detect viral products and initiate the signal cascades that lead to the antiviral response. Several proteins have been identified to play a role in this process, mostly members of the Toll-like receptor and retinoic acid-inducible gene I-like receptor families. These receptors have been demonstrated to function in part by recognizing a diverse yet unique repertoire of nucleic acid substrates. Upon recognition of their ligands, these sensors activate distinct signaling pathways that lead to the secretion of type I interferon and inflammatory cytokines. It remains to be seen, however, if these sensors are redundant or whether each serves a unique function. In this work, we review the current knowledge of viral sensors, speculate on how they may function in vivo, and explore the potential reasons for their diversity.

MeSH Terms
Animals CARD Signaling Adaptor Proteins/metabolism Cytokines/metabolism Host-Pathogen Interactions/immunology Humans Immunity, Innate/immunology Membrane Proteins/genetics,immunology,metabolism Myeloid Differentiation Factor 88/metabolism Nerve Tissue Proteins/genetics,immunology,metabolism Protein Transport RNA Virus Infections/genetics,immunology,metabolism RNA Viruses/physiology RNA, Viral/genetics,immunology,metabolism Receptors, Cell Surface Signal Transduction/immunology Species Specificity Toll-Like Receptors/genetics,immunology,metabolism
Chemicals
CARD Signaling Adaptor Proteins Cytokines Membrane Proteins Myeloid Differentiation Factor 88 Nerve Tissue Proteins RNA, Viral Receptors, Cell Surface Robo3 protein, mouse Toll-Like Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McCartney Stephen A
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Colonna Marco
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Article Info
Journal
Immunological reviews
Abbr.
Immunol Rev
ISSN
1600-065X
DOI
10.1111/j.1600-065X.2008.00726.x
Published
2009-01-00
Pages
87-94
Language
English
Region
England
NLM ID
7702118
PMCID
PMC7165970
Subset
IM
Grants
NIAID NIH HHS · T32 AI007163 · United States
External Links
PubMed source DOI: 10.1111/j.1600-065X.2008.00726.x PMC Full Text View journal details
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