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PMID: 18591413 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

The Journal of experimental medicine ·Vol. 205 ·No. 7 ·2008-07-07 ·Pages 1523-7

Saito T, Gale M

Abstract

Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinflammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specificity were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.

MeSH Terms
Animals Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases/genetics,metabolism Interferon-Induced Helicase, IFIH1 Mice RNA, Double-Stranded/genetics,metabolism RNA, Viral/genetics,metabolism Vesicular Stomatitis/genetics,metabolism Vesiculovirus/genetics,metabolism
Chemicals
RNA, Double-Stranded RNA, Viral Ddx58 protein, mouse Ifih1 protein, mouse DEAD Box Protein 58 DEAD-box RNA Helicases Interferon-Induced Helicase, IFIH1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Saito Takeshi
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Gale Michael
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
1540-9538
DOI
10.1084/jem.20081210
Published
2008-07-07
Pages
1523-7
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2442628
Subset
IM
Grants
NIAID NIH HHS · AI060389 · United States
NIDA NIH HHS · DA024563 · United States
NIAID NIH HHS · R01 AI060389 · United States
NIAID NIH HHS · AI057568 · United States
NIDA NIH HHS · R01 DA024563 · United States
NIAID NIH HHS · R21 AI057568 · United States
NIAID NIH HHS · R56 AI060389 · United States
NIAID NIH HHS · N01AI40035 · United States
Corrections
CommentOn
PMID: 18591409
External Links
PubMed source DOI: 10.1084/jem.20081210 PMC Full Text View journal details
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