A potent new beta2-adrenoceptor blocking agent.

British journal of pharmacology ·Vol. 60 ·No. 3 ·1977-07-00 ·Pages 357-62

Imbs JL, Miesch F, Schwartz J, Velly J, Leclerc G, Mann A, Wermuth CG

Abstract

1 (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new beta2-adrenoceptor blocking agent with a pA2 of 9.23+/-0.25 on isolated trachea. 2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.

MeSH Terms

Adrenergic beta-Antagonists Anesthetics, Local Animals Anti-Arrhythmia Agents Blood Pressure/drug effects Dogs Female Fluorenes/pharmacology Guinea Pigs Heart Rate/drug effects In Vitro Techniques Isoproterenol/antagonists & inhibitors Male Muscle Contraction/drug effects Muscle, Smooth/drug effects Myocardial Contraction/drug effects Propanolamines/pharmacology Rabbits Rats Renin/blood Trachea/drug effects

Chemicals

Adrenergic beta-Antagonists Anesthetics, Local Anti-Arrhythmia Agents Fluorenes Propanolamines Renin Isoproterenol

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Imbs J L

Miesch F

Schwartz J

Velly J

Leclerc G

Mann A

Wermuth C G

References (9)

9 references, click to expand

beta-blocking drugs and renin secretion in the anaesthetized dog.
Clin Sci Mol Med Suppl. 1975 Jun;2:105s-107s PMID: 1077761
Dopamine-induced neurogenic vasodilatation in isolated perfused muscle preparation of the dog.
Naunyn Schmiedebergs Arch Pharmacol. 1975;286(4):413-28 PMID: 238139
Effects of prolonged treatment with adrenergic beta-receptor antagonists on blood pressure, cardiovascular design and reactivity in spontaneously hypertensive rats (SHR).
Acta Physiol Scand. 1974 Aug;91(4):447-57 PMID: 4154700
Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.
Arzneimittelforschung. 1974 Sep;24(9):1275-7 PMID: 4154764
[Modified method for the testing of surface anesthesia on the rabbit cornea, using cocaine, procaine, propranolol, alprenolol, INPEA and verapamil].
Arzneimittelforschung. 1970 Aug;20(8):1140-3 PMID: 5536515
Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.
J Pharmacol Exp Ther. 1970 Jan;171(1):52-61 PMID: 4391468
The actions of selective beta-receptor antagonists on the guinea pig trachea.
Eur J Pharmacol. 1970 Jul 1;11(1):67-74 PMID: 4393450
Pressor effect of beta blocking agents in rats.
Can J Physiol Pharmacol. 1972 Mar;50(3):207-14 PMID: 4402339
A critical evaluation of three methods for the study of adrenergic beta-blocking and anti-arrhythmic agents.
Eur J Pharmacol. 1969 Apr;6(1):49-55 PMID: 4389065

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1977.tb07508.x

Published

1977-07-00

Pages

357-62

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1667284

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1977.tb07508.x PMC Full Text View journal details

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A potent new beta2-adrenoceptor blocking agent.

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