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PMID: 1910171 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Drosophila has a twitchin/titin-related gene that appears to encode projectin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 18 ·1991-09-15 ·Pages 7973-7

Ayme-Southgate A, Vigoreaux J, Benian G, Pardue ML

Abstract

The sequences of twitchin and titin identify a superfamily of muscle proteins whose functions are not completely understood. In spite of their shared structural features, twitchin and titin appear to differ in function. Genetic and molecular evidence suggests that twitchin has a regulatory role in muscle contraction, whereas it has been proposed that titin has a structural function. We report here that Drosophila has a single-copy gene containing the two-motif amino acid sequence pattern that characterizes twitchin and titin. This gene appears to encode projectin, a muscle protein that is thought to play a structural role in asynchronous flight muscle but may have a role like that of twitchin in synchronous muscle. Thus Drosophila appears to be a case where the apparently diverged functions of twitchin and titin are encoded by a single gene.

MeSH Terms

Amino Acid Sequence Animals Caenorhabditis/genetics Caenorhabditis elegans Proteins Calmodulin-Binding Proteins Cloning, Molecular Connectin Drosophila melanogaster/genetics Genes Helminth Proteins/genetics Molecular Sequence Data Muscle Proteins/genetics Polymerase Chain Reaction Protein Kinases Restriction Mapping

Chemicals

Caenorhabditis elegans Proteins Calmodulin-Binding Proteins Connectin Helminth Proteins Muscle Proteins unc-22 protein, C elegans Protein Kinases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ayme-Southgate A

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Vigoreaux J

Benian G

Pardue M L

References (20)

20 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.88.18.7973

Published

1991-09-15

Pages

7973-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC52427

Subset

Databases

GENBANK

M73433, M73434, M73435, M74452, M94197, M94198, M94199, M94200, S55106, X53420

External Links

PubMed source DOI: 10.1073/pnas.88.18.7973 PMC Full Text View journal details

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Drosophila has a twitchin/titin-related gene that appears to encode projectin.

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