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PMID: 1906371 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients.

Clinical microbiology reviews ·Vol. 4 ·No. 2 ·1991-04-00 ·Pages 191-206

May TB, Shinabarger D, Maharaj R, Kato J, Chu L, DeVault JD, Roychoudhury S, Zielinski NA, Berry A, Rothmel RK

Abstract

Pulmonary infection by mucoid, alginate-producing Pseudomonas aeruginosa is the leading cause of mortality among patients suffering from cystic fibrosis. Alginate-producing P. aeruginosa is uniquely associated with the environment of the cystic fibrosis-affected lung, where alginate is believed to increase resistance to both the host immune system and antibiotic therapy. Recent evidence indicates that P. aeruginosa is most resistant to antibiotics when the infecting cells are present as a biofilm, as they appear to be in the lungs of cystic fibrosis patients. Inhibition of the protective alginate barrier with nontoxic compounds targeted against alginate biosynthetic and regulatory proteins may prove useful in eradicating P. aeruginosa from this environment. Our research has dealt with elucidating the biosynthetic pathway and regulatory mechanism(s) responsible for alginate synthesis by P. aeruginosa. This review summarizes reports on the role of alginate in cystic fibrosis-associated pulmonary infections caused by P. aeruginosa and provides details about the biosynthesis and regulation of this exopolysaccharide.

MeSH Terms
Alginates/metabolism Base Sequence Cystic Fibrosis/complications DNA, Bacterial/chemistry Humans Lung/microbiology Lung Diseases/complications,microbiology Molecular Sequence Data Promoter Regions, Genetic Pseudomonas Infections/complications,microbiology Pseudomonas aeruginosa/genetics,metabolism
Chemicals
Alginates DNA, Bacterial
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
May T B
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60612.
Shinabarger D
Maharaj R
Kato J
Chu L
DeVault J D
Roychoudhury S
Zielinski N A
Berry A
Rothmel R K
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.4.2.191
Published
1991-04-00
Pages
191-206
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC358191
Subset
IM
Grants
NIAID NIH HHS · AI-16790-12 · United States
External Links
PubMed source DOI: 10.1128/CMR.4.2.191 PMC Full Text View journal details
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