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PMID: 1904152 Published · ppublish English Journal Article

An estrogen-dependent polysomal protein binds to the 5' untranslated region of the chicken vitellogenin mRNA.

Nucleic acids research ·Vol. 19 ·No. 9 ·1991-05-11 ·Pages 2289-94

Liang HM, Jost JP

Abstract

An estrogen-dependent protein present in chicken liver polysomes binds to the 5' untranslated region of the chicken vitellogenin II mRNA. Competition binding assays with different RNAs indicate that the binding of the polysomal protein to this region is sequence specific. Of the tissues tested, this RNA binding activity is liver specific. In vivo kinetics of appearance of the binding activity following a single injection of estrogen to immature chicks are similar to the rate of accumulation of vitellogenin mRNA. The molecular weight of the polysomal protein has been estimated to be 66,000 on the basis of UV crosslinking and subsequent SDS polyacrylamide gel electrophoresis. In vitro RNA decay assays carried out with a minivitellogenin mRNA suggest that the estrogen-dependent polysomal protein may be involved in the estrogen-mediated stabilization of the chicken vitellogenin II mRNA.

MeSH Terms
Animals Base Sequence Binding, Competitive Carrier Proteins/metabolism Chickens DNA Estrogens/physiology Female Introns Kinetics Liver/metabolism Male Molecular Sequence Data Molecular Weight Organ Specificity/genetics Polyribosomes/metabolism RNA, Messenger/metabolism RNA-Binding Proteins Vitellogenins/genetics
Chemicals
Carrier Proteins Estrogens RNA, Messenger RNA-Binding Proteins Vitellogenins DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liang H M
Friedrich-Miescher Institute, Basel, Switzerland.
Jost J P
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36 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/19.9.2289
Published
1991-05-11
Pages
2289-94
Language
English
Region
England
NLM ID
0411011
PMCID
PMC329432
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/19.9.2289 PMC Full Text View journal details
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