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PMID: 19026532 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Molecular characterisation of the tumour microenvironment in breast cancer.

European journal of cancer (Oxford, England : 1990) ·Vol. 44 ·No. 18 ·2008-12-00 ·Pages 2760-5

Hu M, Polyak K

Abstract

The tumour microenvironment plays important roles in cancer initiation, growth, progression, invasion and metastasis, yet the molecular basis underlying these tumour-promoting effects is not fully delineated. Recent advances in gene expression, genetic and epigenetic profiling of stromal cells have improved our understanding of how mesenchymal-epithelial cell interactions may create a permissive microenvironment for malignancy and identified potential targets for cancer prevention and treatment including chemokine and cytokine networks. However, translating these findings into clinical practice may be difficult due to the complexity and redundancy of the interactions and the inherent ability of tumour epithelial cells to evolve and thrive in diverse environmental conditions.

MeSH Terms
Breast Neoplasms/genetics,pathology Cell Communication Disease Progression Epithelial Cells/pathology Female Humans Paracrine Communication Stromal Cells/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hu Min
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Polyak Kornelia
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Article Info
Journal
European journal of cancer (Oxford, England : 1990)
Abbr.
Eur J Cancer
ISSN
1879-0852
DOI
10.1016/j.ejca.2008.09.038
Published
2008-12-00
Epub
2008-00-19
Pages
2760-5
Language
English
Region
England
NLM ID
9005373
PMCID
PMC2729518
Subset
IM
Grants
NCI NIH HHS · CA116235 · United States
NCI NIH HHS · P50 CA089393-080014 · United States
NCI NIH HHS · R01 CA116235-02 · United States
NCI NIH HHS · CA94074 · United States
NCI NIH HHS · CA89393 · United States
NCI NIH HHS · R01 CA094074 · United States
NCI NIH HHS · R01 CA116235-03 · United States
NCI NIH HHS · P50 CA089393 · United States
NCI NIH HHS · R01 CA116235 · United States
NCI NIH HHS · P50 CA089393-070014 · United States
External Links
PubMed source DOI: 10.1016/j.ejca.2008.09.038 PMC Full Text View journal details
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