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PMID: 19022387 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins.

Molecular and cellular neurosciences ·Vol. 40 ·No. 2 ·2009-02-00 ·Pages 128-42

Merianda TT, Lin AC, Lam JS, Vuppalanchi D, Willis DE, Karin N, Holt CE, Twiss JL

Abstract

Subcellular localization of protein synthesis provides a means to regulate the protein composition in far reaches of a cell. This localized protein synthesis gives neuronal processes autonomy to rapidly respond to extracellular stimuli. Locally synthesized axonal proteins enable neurons to respond to guidance cues and can help to initiate regeneration after injury. Most studies of axonal mRNA translation have concentrated on cytoplasmic proteins. While ultrastructural studies suggest that axons do not have rough endoplasmic reticulum or Golgi apparatus, mRNAs for transmembrane and secreted proteins localize to axons. Here, we show that growing axons with protein synthetic activity contain ER and Golgi components needed for classical protein synthesis and secretion. Isolated axons have the capacity to traffic locally synthesized proteins into secretory pathways and inhibition of Golgi function attenuates translation-dependent axonal growth responses. Finally, the capacity for secreting locally synthesized proteins in axons appears to be increased by injury.

MeSH Terms
Animals Axons/metabolism,pathology,ultrastructure Biological Transport/physiology Biomarkers/metabolism Calcium Channels/genetics,metabolism Cell Membrane/metabolism Cells, Cultured Endoplasmic Reticulum/metabolism Ganglia, Spinal/cytology Golgi Apparatus/metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Male Nerve Regeneration/physiology Nerve Tissue Proteins/genetics,metabolism Potassium Channels/genetics,metabolism Rats Rats, Sprague-Dawley Secretory Pathway/physiology Xenopus laevis/physiology
Chemicals
Biomarkers Cacna1a protein, rat Calcium Channels Faim2 protein, rat HCN4 protein, rat Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Nerve Tissue Proteins Potassium Channels
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Merianda Tanuja T
Nemours Biomedical Research, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA.
Lin Andrew C
Lam Joyce S Y
Vuppalanchi Deepika
Willis Dianna E
Karin Norman
Holt Christine E
Twiss Jeffery L
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Article Info
Journal
Molecular and cellular neurosciences
Abbr.
Mol Cell Neurosci
ISSN
1095-9327
Published
2009-02-00
Epub
2008-00-22
Pages
128-42
Language
English
Region
United States
NLM ID
9100095
PMCID
PMC3794446
Subset
IM
Grants
NINDS NIH HHS · R01 NS049041 · United States
Medical Research Council · G0501592 · United Kingdom
Wellcome Trust · 085314 · United Kingdom
NINDS NIH HHS · R01-NS049041 · United States
Wellcome Trust · United Kingdom
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