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PMID: 19011659 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.

Nature reviews. Microbiology ·Vol. 7 ·No. 1 ·2009-01-00 ·Pages 13-24

Isberg RR, O'Connor TJ, Heidtman M

Abstract

The pathogenesis of Legionella pneumophila is derived from its growth within lung macrophages after aerosols are inhaled from contaminated water sources. Interest in this bacterium stems from its ability to manipulate host cell vesicular-trafficking pathways and establish a membrane-bound replication vacuole, making it a model for intravacuolar pathogens. Establishment of the replication compartment requires a specialized translocation system that transports a large cadre of protein substrates across the vacuolar membrane. These substrates regulate vesicle traffic and survival pathways in the host cell. This Review focuses on the strategies that L. pneumophila uses to establish intracellular growth and evaluates why this microorganism has accumulated an unprecedented number of translocated substrates that are targeted at host cells.

MeSH Terms
Legionella pneumophila/growth & development,pathogenicity,physiology Macrophages/microbiology Vacuoles/microbiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Isberg Ralph R
Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. Ralph.Isberg@Tufts.edu
O'Connor Tamara J
Heidtman Matthew
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro1967
Email
ralph.isberg@tufts.edu
Published
2009-01-00
Epub
2008-00-17
Pages
13-24
Language
English
Region
England
NLM ID
101190261
PMCID
PMC2631402
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIAID NIH HHS · F32 AI069686-02 · United States
External Links
PubMed source DOI: 10.1038/nrmicro1967 PMC Full Text View journal details
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