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PMID: 9452389 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Conjugative transfer by the virulence system of Legionella pneumophila.

Science (New York, N.Y.) ·Vol. 279 ·No. 5352 ·1998-02-06 ·Pages 873-6

Vogel JP, Andrews HL, Wong SK, Isberg RR

Abstract

Legionella pneumophila, the causative agent of Legionnaires' pneumonia, replicates within alveolar macrophages by preventing phagosome-lysosome fusion. Here, a large number of mutants called dot (defective for organelle trafficking) that were unable to replicate intracellularly because of an inability of the bacteria to alter the endocytic pathway of macrophages were isolated. The dot virulence genes encoded a large putative membrane complex that functioned as a secretion system that was able to transfer plasmid DNA from one cell to another.

MeSH Terms
Antigens, CD/analysis Bacterial Proteins/genetics,physiology Conjugation, Genetic Endocytosis Escherichia coli/genetics Genes, Bacterial Humans Legionella pneumophila/genetics,growth & development,pathogenicity Lysosome-Associated Membrane Glycoproteins Lysosomes/physiology Macrophages, Alveolar/microbiology Membrane Glycoproteins/analysis Molecular Sequence Data Mutation Phagosomes/physiology Plasmids Sequence Deletion Tumor Cells, Cultured Virulence
Chemicals
Antigens, CD Bacterial Proteins Lysosome-Associated Membrane Glycoproteins Membrane Glycoproteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Vogel J P
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
Andrews H L
Wong S K
Isberg R R
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.279.5352.873
Published
1998-02-06
Pages
873-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
AF026533, AF026534
External Links
PubMed source DOI: 10.1126/science.279.5352.873 View journal details
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