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PMID: 18997396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Synthesis and anti-angiogenic activity of cortistatin analogs.

Bioscience, biotechnology, and biochemistry ·Vol. 72 ·No. 11 ·2008-11-00 ·Pages 2992-7

Sato Y, Kamiyama H, Usui T, Saito T, Osada H, Kuwahara S, Kiyota H

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

MeSH Terms

Angiogenesis Inhibitors/chemical synthesis,chemistry,pharmacology Animals Cell Line Cell Movement/drug effects Cell Proliferation/drug effects Endothelial Cells/cytology,drug effects Estrone/analogs & derivatives Humans Mice Neuropeptides/chemical synthesis,chemistry,pharmacology Vascular Endothelial Growth Factor A/pharmacology

Chemicals

Angiogenesis Inhibitors Neuropeptides Vascular Endothelial Growth Factor A cortistatin Estrone

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Sato Yuuki

Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

Kamiyama Hiroshi

Usui Takeo

Saito Tamio

Osada Hiroyuki

Kuwahara Shigefumi

Kiyota Hiromasa

Article Info

Journal

Bioscience, biotechnology, and biochemistry

Abbr.

Biosci Biotechnol Biochem

ISSN

1347-6947

DOI

10.1271/bbb.80562

Published

2008-11-00

Epub

2008-00-07

Pages

2992-7

Language

English

Region

England

NLM ID

9205717

Subset

External Links

PubMed source DOI: 10.1271/bbb.80562 View journal details

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Synthesis and anti-angiogenic activity of cortistatin analogs.

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