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PMID: 18852696 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Biological principles of microRNA-mediated regulation: shared themes amid diversity.

Nature reviews. Genetics ·Vol. 9 ·No. 11 ·2008-11-00 ·Pages 831-42

Flynt AS, Lai EC

Abstract

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression. Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease.

MeSH Terms
Animals Body Patterning/genetics Gene Expression Regulation/physiology Gene Regulatory Networks/genetics MicroRNAs/biosynthesis,genetics,physiology Models, Genetic Plants/genetics
Chemicals
MicroRNAs
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Flynt Alex S
Sloan-Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Labs, 1275 York Avenue, Box 252, New York, New York 10065, USA.
Lai Eric C
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2455
Published
2008-11-00
Pages
831-42
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2729318
Subset
IM
Grants
NIGMS NIH HHS · R01 GM083300 · United States
NIGMS NIH HHS · R01 GM083300-01 · United States
NIGMS NIH HHS · R01-GM083300 · United States
External Links
PubMed source DOI: 10.1038/nrg2455 PMC Full Text View journal details
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