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PMID: 1884753 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Calcium-binding proteins are concentrated in the CA2 field of the monkey hippocampus: a possible key to this region's resistance to epileptic damage.

Experimental brain research ·Vol. 85 ·No. 1 ·1991-00-00 ·Pages 129-36

Leranth C, Ribak CE

Abstract

Previous immunocytochemical studies have shown a heterogeneous distribution of parvalbumin (PA) and calbindin (CB) in the rat hippocampal formation. The results of the present study showed a heterogeneous distribution of PA and CB in primate Ammon's horn. The density and intensity of immunoreactivity for both of these calcium-binding proteins was greatest in CA2 as compared to CA1 and CA3. CB-immunoreactivity was localized to the cell bodies, dendrites, and axon initial segments of pyramidal cells whereas PA-immunostaining was found in the axon terminals, dendrites and cell bodies of interneurons that have features similar to GABAergic inhibitory neurons. Based on previous studies that have shown a protective role of calcium-binding proteins in neurons exposed to hyperstimulation, these results suggest that the resistance of CA2 pyramidal cells in temporal lobe epilepsy is due to the high concentration of CB and PA in this region of Ammon's horn.

MeSH Terms
Animals Calcium-Binding Proteins/metabolism Chlorocebus aethiops Epilepsy/pathology Female Hippocampus/metabolism,pathology Immunohistochemistry Male Microscopy, Electron Parvalbumins/metabolism Pyramidal Tracts/cytology,metabolism
Chemicals
Calcium-Binding Proteins Parvalbumins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Leranth C
Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06510.
Ribak C E
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00229993
Published
1991-00-00
Pages
129-36
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
Grants
NINDS NIH HHS · NS-15669 · United States
NINDS NIH HHS · NS-26068 · United States
External Links
PubMed source DOI: 10.1007/BF00229993 View journal details
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