The TPR snap helix: a novel protein repeat motif from mitosis to transcription.

Trends in biochemical sciences ·Vol. 16 ·No. 5 ·1991-05-00 ·Pages 173-7

Goebl M, Yanagida M

Abstract

The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. These multi-domain proteins all contain tandemly arranged repeats of a 34-amino acid motif that are presumed to form helix-turn structures, each with a 'knob' and 'hole', acting as helix-associating domains.

Related Genes

TPR

MeSH Terms

Amino Acid Sequence Animals DNA-Binding Proteins Drosophila Fungal Proteins/genetics Genes, Fungal/genetics,physiology Mitosis/physiology Molecular Sequence Data Protein Conformation Repetitive Sequences, Nucleic Acid Saccharomyces cerevisiae/genetics,physiology Sequence Homology, Nucleic Acid Transcription, Genetic/physiology

Chemicals

DNA-Binding Proteins Fungal Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Goebl M

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122.

Yanagida M

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(91)90070-c

Published

1991-05-00

Pages

173-7

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/0968-0004(91)90070-c View journal details

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The TPR snap helix: a novel protein repeat motif from mitosis to transcription.

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