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PMID: 188050 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Biological and serological characterization of radiation leukemia virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 12 ·1976-12-00 ·Pages 4675-9

Declève A, Lieberman M, Ihle JN, Kaplan HS

Abstract

Radiation leukemia virus, isolated from radiation-induced lymphomas in C57BL/Ka mice and propagated in that strain, is thymotropic and leukemogenic in vivo but replicates poorly, if at all, in mouse and mink fibroblast cultures in vitro. Comparative studies indicate that this naturally occurring virus is distinct from the previously recognized classes of endogenous murine ecotropic and xenotropic C-type viruses which are capable of replication on fibroblasts (fibrotropic) but are neither thymotropic nor leukemogenic. These studies also demonstrate that a differentiation-specific restriction system governing the replication of the murine ecotropic C-type viruses operates in addition to the previously defined Fv-1 and SRV gene restriction systems.

MeSH Terms
Animals Antigens, Viral/analysis Cross Reactions Female Fibroblasts/microbiology Glycoproteins/immunology Leukemia Virus, Murine/classification,immunology,radiation effects Male Mice Mice, Inbred Strains Serotyping Species Specificity Thymus Gland/microbiology Viral Proteins/immunology Virus Replication
Chemicals
Antigens, Viral Glycoproteins Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Declève A
Lieberman M
Ihle J N
Kaplan H S
References (27)
27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.12.4675
Published
1976-12-00
Pages
4675-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431593
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.12.4675 PMC Full Text View journal details
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