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PMID: 174115 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

New gene locus modifying susceptibility to certain B-tropic murine leukemia viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 2 ·1976-02-00 ·Pages 585-90

Declève A, Niwa O, Kojola J, Kaplan HS

Abstract

A new gene, SRV, the dominant allele of which occurs in mice of strain C57BL, independently modifies the slope ("hitness") and level of sensitivity of the titration curves obtained when one subclass of B-tropic murine leukemia viruses is propagated on mouse embryo cells of nonpermissive Fv-1 genotypes. Replication of another subclass of B-tropic viruses is not modified with respect to hitness, and that of N-tropic viruses is not affected.

MeSH Terms
Animals Cells, Cultured Genes Genes, Dominant Genotype Hybridization, Genetic Leukemia Virus, Murine/growth & development Mice Mice, Inbred BALB C Mice, Inbred C57BL Models, Biological Species Specificity Thymus Gland/microbiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Declève A
Niwa O
Kojola J
Kaplan H S
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21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.2.585
Published
1976-02-00
Pages
585-90
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC335955
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.2.585 PMC Full Text View journal details
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