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PMID: 18804122 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

AT2 receptors: functional relevance in cardiovascular disease.

Pharmacology & therapeutics ·Vol. 120 ·No. 3 ·2008-12-00 ·Pages 292-316

Jones ES, Vinh A, McCarthy CA, Gaspari TA, Widdop RE

Abstract

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range of cardiovascular pathologies and diseases via angiotensin type 1 receptor (AT1R) activation. On the other hand, tElsevier Inc.he angiotensin type 2 receptor (AT2R) is thought to counter-regulate AT1R function. In this review, we describe the enhanced expression and function of AT2R in various cardiovascular disease settings. In addition, we illustrate that the RAS consists of a family of angiotensin peptides that exert cardiovascular effects that are often distinct from those of Ang II. During cardiovascular disease, there is likely to be an increased functional importance of AT2R, stimulated by Ang II, or even shorter angiotensin peptide fragments, to limit AT1R-mediated overactivity and cardiovascular pathologies.

MeSH Terms
Aging Angiotensins/metabolism,physiology Animals Cardiovascular Diseases/metabolism,physiopathology Diabetes Mellitus/metabolism Humans Kidney Diseases/metabolism Receptor, Angiotensin, Type 1/metabolism Receptor, Angiotensin, Type 2/physiology Renin-Angiotensin System/physiology
Chemicals
Angiotensins Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jones Emma S
Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia.
Vinh Antony
McCarthy Claudia A
Gaspari Tracey A
Widdop Robert E
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Article Info
Journal
Pharmacology & therapeutics
Abbr.
Pharmacol Ther
ISSN
0163-7258
DOI
10.1016/j.pharmthera.2008.08.009
Published
2008-12-00
Epub
2008-00-31
Pages
292-316
Language
English
Region
England
NLM ID
7905840
PMCID
PMC7112668
Subset
IM
External Links
PubMed source DOI: 10.1016/j.pharmthera.2008.08.009 PMC Full Text View journal details
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