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PMID: 17464936 Published · ppublish English Journal Article Review

The emerging role of ACE2 in physiology and disease.

The Journal of pathology ·Vol. 212 ·No. 1 ·2007-05-00 ·Pages 1-11

Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H

Abstract

The renin-angiotensin-aldosterone system (RAAS) is a key regulator of systemic blood pressure and renal function and a key player in renal and cardiovascular disease. However, its (patho)physiological roles and its architecture are more complex than initially anticipated. Novel RAAS components that may add to our understanding have been discovered in recent years. In particular, the human homologue of ACE (ACE2) has added a higher level of complexity to the RAAS. In a short period of time, ACE2 has been cloned, purified, knocked-out, knocked-in; inhibitors have been developed; its 3D structure determined; and new functions have been identified. ACE2 is now implicated in cardiovascular and renal (patho)physiology, diabetes, pregnancy, lung disease and, remarkably, ACE2 serves as a receptor for SARS and NL63 coronaviruses. This review covers available information on the genetic, structural and functional properties of ACE2. Its role in a variety of (patho)physiological conditions and therapeutic options of modulation are discussed.

MeSH Terms
Aldosterone/metabolism Angiotensin-Converting Enzyme 2 Animals Cardiovascular Diseases/metabolism Coronavirus/physiology Female Humans Hypertension/enzymology Kidney/metabolism Lung Diseases/enzymology Male Myocardium/enzymology Peptidyl-Dipeptidase A/physiology Pregnancy Pregnancy Complications/enzymology Renin-Angiotensin System/physiology SARS Virus/physiology
Chemicals
Aldosterone Peptidyl-Dipeptidase A ACE2 protein, human Angiotensin-Converting Enzyme 2
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Hamming I
Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands. i.hamming@path.umcg.nl
Cooper M E
Haagmans B L
Hooper N M
Korstanje R
Osterhaus A D M E
Timens W
Turner A J
Navis G
van Goor H
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Article Info
Journal
The Journal of pathology
Abbr.
J Pathol
ISSN
0022-3417
DOI
10.1002/path.2162
Email
i.hamming@path.umcg.nl
Published
2007-05-00
Pages
1-11
Language
English
Region
England
NLM ID
0204634
PMCID
PMC7167724
Subset
IM
External Links
PubMed source DOI: 10.1002/path.2162 PMC Full Text View journal details
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