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PMID: 1879941 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.

Infection and immunity ·Vol. 59 ·No. 9 ·1991-09-00 ·Pages 3280-3

Rockett KA, Awburn MM, Cowden WB, Clark IA

Abstract

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.

MeSH Terms
Animals Colony Count, Microbial Lethal Dose 50 Nitric Oxide/pharmacology Nitroso Compounds/pharmacology Plasmodium falciparum/drug effects,growth & development
Chemicals
Nitroso Compounds Nitric Oxide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rockett K A
Division of Cell Biology, John Curtin School of Medical Research, Canberra, A.C.T., Australia.
Awburn M M
Cowden W B
Clark I A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.59.9.3280-3283.1991
Published
1991-09-00
Pages
3280-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258164
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.59.9.3280-3283.1991 PMC Full Text View journal details
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