The effect of nitric oxide on bacteria.

Applied microbiology ·Vol. 10 ·1962-05-00 ·Pages 185-9

SHANK JL, SILLIKER JH, HARPER RH

Abstract

Nitric oxide, as well as several other oxides of nitrogen, were assayed for their antibacterial action. It is shown that nitric oxide has virtually no effect on bacteria, whereas both NaNO(3) and NaNO(2) appear to have either neutral or stimulatory effects. It is suggested that the formation of nitrous acid is mainly responsible for the quantitative as well as the qualitative changes that occur in the bacterial flora of cured meat. A pH-dependent "nitrite cycle" is presented to account for the production of nitrous acid in cured meat systems.

Keywords

BACTERIA/pharmacology NITRATES/pharmacology

MeSH Terms

Bacteria/pharmacology Hydrogen-Ion Concentration Nitrates/pharmacology Nitric Oxide Nitrites Nitrogen Nitrous Acid

Chemicals

Nitrates Nitrites Nitric Oxide Nitrogen Nitrous Acid

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

SHANK J L

SILLIKER J H

HARPER R H

References (9)

9 references, click to expand

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J Bacteriol. 1939 Dec;38(6):613-29 PMID: 16560275
The formation of hyponitrous acid as an intermediate compound in the biological or photochemical oxidation of ammonia to nitrous acid: Chemical reactions.
Biochem J. 1934;28(4):1575-82 PMID: 16745549
The Production of Hydroxylamine by the Reduction of Nitrates and Nitrites by Various Pure Cultures of Bacteria.
J Bacteriol. 1932 Dec;24(6):489-92 PMID: 16559600
Oxides of nitrogen: their occurrence, toxicity, hazard; a brief review.
AMA Arch Ind Health. 1959 May;19(5):479-86 PMID: 13636460
[Biochemical mechanism of the action of nitrite in the preservation of meats; physiochemical conditions favorable to its bacteriostatic action].
C R Seances Soc Biol Fil. 1954 May;148(9-10):819-21 PMID: 13219801
The action of nitrous acid on pepsin.
Biochem J. 1938 Mar;32(3):542-51 PMID: 16746652
Factors affecting the bacteriostatic action of sodium nitrite.
Appl Microbiol. 1955 May;3(3):154-9 PMID: 14377383
Tellurite-glycine agar: a selective plating medium for the quantitative detection of coagulase-positive staphylococci.
J Bacteriol. 1955 Dec;70(6):686-90 PMID: 13271314

Article Info

Journal

Applied microbiology

Abbr.

Appl Microbiol

ISSN

0003-6919

DOI

10.1128/am.10.3.185-189.1962

Published

1962-05-00

Pages

185-9

Language

English

Region

United States

NLM ID

7605802

PMCID

PMC1057838

Subset

External Links

PubMed source DOI: 10.1128/am.10.3.185-189.1962 PMC Full Text

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