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PMID: 18786826 Published · ppublish English Journal Article Review

Structure, dynamics and function of nuclear pore complexes.

Trends in cell biology ·Vol. 18 ·No. 10 ·2008-10-00 ·Pages 456-66

D'Angelo MA, Hetzer MW

Abstract

Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.

MeSH Terms
Animals Cell Nucleus/physiology Chromatin/physiology Cytoskeleton/physiology Humans Mitosis/physiology Nuclear Envelope/physiology Nuclear Pore/chemistry,physiology Nuclear Pore Complex Proteins/chemistry,physiology Saccharomyces cerevisiae/metabolism
Chemicals
Chromatin Nuclear Pore Complex Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
D'Angelo Maximiliano A
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Hetzer Martin W
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2008.07.009
Published
2008-10-00
Epub
2008-00-09
Pages
456-66
Language
English
Region
England
NLM ID
9200566
PMCID
PMC2697926
Subset
IM
Grants
NIGMS NIH HHS · R01 GM057438 · United States
NIGMS NIH HHS · R01 GM057438-10A1 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2008.07.009 PMC Full Text View journal details
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