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PMID: 18786383 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Coordinating speed and amplitude in G-protein signaling.

Current biology : CB ·Vol. 18 ·No. 17 ·2008-09-09 ·Pages R777-R783

Ross EM

Abstract

G-protein-mediated signaling is intrinsically kinetic. Signal output at steady state is a balance of the rates of GTP binding, which causes activation, and of GTP hydrolysis, which terminates activation. This GTPase catalytic cycle is regulated by receptors, which accelerate GTP binding, and GTPase-activating proteins (GAPs), which accelerate hydrolysis. Receptors and GAPs similarly control the rates of signal initiation and termination. To allow independent control of signal amplitude and of the rates of turning the signal on and off, the activities of receptors and GAPs must be coordinated. Here, the principles of such coordination and the mechanisms by which it is achieved are discussed.

MeSH Terms
Enzyme Activation GTP-Binding Proteins/chemistry,metabolism GTPase-Activating Proteins/physiology Kinetics Models, Biological Signal Transduction
Chemicals
GTPase-Activating Proteins GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ross Elliott M
Department of Pharmacology, Graduate Programs in Molecular Biophysics and Cell Regulation, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA. ross@utsw.swmed.edu
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Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/j.cub.2008.07.035
Email
ross@utsw.swmed.edu
Published
2008-09-09
Pages
R777-R783
Language
English
Region
England
NLM ID
9107782
PMCID
PMC2654212
Subset
IM
Grants
NIGMS NIH HHS · R01 GM030355 · United States
NIGMS NIH HHS · R01 GM030355-27 · United States
NIGMS NIH HHS · R37 GM030355 · United States
NIGMS NIH HHS · GM30355 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1016/j.cub.2008.07.035 PMC Full Text View journal details
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