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PMID: 17173929 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

How regulators of G protein signaling achieve selective regulation.

Journal of molecular biology ·Vol. 366 ·No. 2 ·2007-02-16 ·Pages 349-65

Xie GX, Palmer PP

Abstract

The regulators of G protein signaling (RGS) are a family of cellular proteins that play an essential regulatory role in G protein-mediated signal transduction. There are multiple RGS subfamilies consisting of over 20 different RGS proteins. They are basically the guanosine triphosphatase (GTPase)-accelerating proteins that specifically interact with G protein alpha subunits. RGS proteins display remarkable selectivity and specificity in their regulation of receptors, ion channels, and other G protein-mediated physiological events. The molecular and cellular mechanisms underlying such selectivity are complex and cooperate at many different levels. Recent research data have provided strong evidence that the spatiotemporal-specific expression of RGS proteins and their target components, as well as the specific protein-protein recognition and interaction through their characteristic structural domains and functional motifs, are determinants for RGS selectivity and specificity. Other molecular mechanisms, such as alternative splicing and scaffold proteins, also significantly contribute to RGS selectivity. To pursue a thorough understanding of the mechanisms of RGS selective regulation will be of great significance for the advancement of our knowledge of molecular and cellular signal transduction.

MeSH Terms
Animals GTP-Binding Proteins/metabolism Gene Expression Regulation Humans Ion Channel Gating/physiology RGS Proteins/chemistry,classification,genetics,metabolism,physiology Receptors, G-Protein-Coupled/metabolism Signal Transduction
Chemicals
RGS Proteins Receptors, G-Protein-Coupled GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Xie Guo-Xi
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
Palmer Pamela Pierce
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Article Info
Journal
Journal of molecular biology
Abbr.
J Mol Biol
ISSN
0022-2836
DOI
10.1016/j.jmb.2006.11.045
Published
2007-02-16
Epub
2006-00-15
Pages
349-65
Language
English
Region
England
NLM ID
2985088R
PMCID
PMC1805491
Subset
IM
Grants
NINDS NIH HHS · R01 NS042593-01A2 · United States
NINDS NIH HHS · R01 NS042593 · United States
NINDS NIH HHS · NS042593 · United States
NINDS NIH HHS · R01 NS042593-02 · United States
NINDS NIH HHS · R01 NS042593-03 · United States
External Links
PubMed source DOI: 10.1016/j.jmb.2006.11.045 PMC Full Text View journal details
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