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PMID: 18698328 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Transcription-independent functions of MYC: regulation of translation and DNA replication.

Nature reviews. Molecular cell biology ·Vol. 9 ·No. 10 ·2008-10-00 ·Pages 810-5

Cole MD, Cowling VH

Abstract

MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

MeSH Terms
Animals DNA Replication/genetics Genes, myc Humans Methylation Models, Biological Models, Genetic Neoplasms/genetics,metabolism Protein Biosynthesis Proto-Oncogene Proteins c-myc/genetics,metabolism RNA Caps/genetics,metabolism RNA, Messenger/genetics,metabolism Transcription Factors/genetics,metabolism
Chemicals
Proto-Oncogene Proteins c-myc RNA Caps RNA, Messenger Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cole Michael D
Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA.
Cowling Victoria H
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2467
Published
2008-10-00
Epub
2008-00-13
Pages
810-5
Language
English
Region
England
NLM ID
100962782
PMCID
PMC3880805
Subset
IM
Grants
Medical Research Council · G0700240 · United Kingdom
NCI NIH HHS · P30 CA023108 · United States
NCI NIH HHS · R01 CA055248 · United States
External Links
PubMed source DOI: 10.1038/nrm2467 PMC Full Text View journal details
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