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PMID: 16213209 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

Right place, right time, and only once: replication initiation in metazoans.

Cell ·Vol. 123 ·No. 1 ·2005-10-07 ·Pages 13-24

Machida YJ, Hamlin JL, Dutta A

Abstract

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

MeSH Terms

Animals Cell Cycle Proteins/genetics,metabolism Chromatin/genetics,metabolism DNA Helicases/genetics,metabolism DNA Replication/physiology Epigenesis, Genetic/physiology Feedback, Physiological/physiology Genes, cdc/physiology Humans Mitosis/physiology Replication Origin/genetics

Chemicals

Cell Cycle Proteins Chromatin DNA Helicases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Machida Yuichi J

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Hamlin Joyce L

Dutta Anindya

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2005.09.019

Published

2005-10-07

Pages

13-24

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

NCI NIH HHS · R01 CA060499 · United States

CGH CDC HHS · GH003157 · United States

NIGMS NIH HHS · GM26108 · United States

NCI NIH HHS · R01 CA060499-12 · United States

NCI NIH HHS · CA60499 · United States

External Links

PubMed source DOI: 10.1016/j.cell.2005.09.019 View journal details

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Right place, right time, and only once: replication initiation in metazoans.

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