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PMID: 18650916 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

From endoplasmic-reticulum stress to the inflammatory response.

Nature ·Vol. 454 ·No. 7203 ·2008-07-24 ·Pages 455-62

Zhang K, Kaufman RJ

Abstract

The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.

MeSH Terms
Animals Disease Endoplasmic Reticulum/metabolism,pathology Humans Inflammation/metabolism,pathology JNK Mitogen-Activated Protein Kinases/metabolism NF-kappa B/metabolism Protein Folding Reactive Oxygen Species/metabolism
Chemicals
NF-kappa B Reactive Oxygen Species JNK Mitogen-Activated Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhang Kezhong
Department of Biological Chemistry, The University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA.
Kaufman Randal J
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature07203
Published
2008-07-24
Pages
455-62
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2727659
Subset
IM
Grants
NIDDK NIH HHS · R37 DK042394-10 · United States
NHLBI NIH HHS · P01 HL057346 · United States
NIDDK NIH HHS · DK042394 · United States
NHLBI NIH HHS · R01 HL052173-11 · United States
NIDDK NIH HHS · R37 DK042394 · United States
NHLBI NIH HHS · R01 HL052173-12 · United States
NHLBI NIH HHS · P01 HL057346-100006 · United States
NIDDK NIH HHS · R01 DK042394-09 · United States
NHLBI NIH HHS · HL057346 · United States
NHLBI NIH HHS · HL052173 · United States
NHLBI NIH HHS · P01 HL057346-11A18575 · United States
Howard Hughes Medical Institute · United States
NIDDK NIH HHS · R37 DK042394-11 · United States
NIDDK NIH HHS · R01 DK042394 · United States
NHLBI NIH HHS · R01 HL052173 · United States
External Links
PubMed source DOI: 10.1038/nature07203 PMC Full Text View journal details
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