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PMID: 18632860 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer.

Journal of virology ·Vol. 82 ·No. 19 ·2008-10-00 ·Pages 9329-36

Contreras-Galindo R, Kaplan MH, Leissner P, Verjat T, Ferlenghi I, Bagnoli F, Giusti F, Dosik MH, Hayes DF, Gitlin SD, Markovitz DM

Abstract

Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no longer replicate. However, certain human tumor cell lines have been shown to release endogenous retroviral particles. Here we show that RNA from human endogenous retrovirus K (HERV-K) (HML-2), a relatively recent entrant into the human genome, can be found in very high titers in the plasma of patients with lymphomas and breast cancer as measured by either reverse transcriptase PCR or nucleic acid sequence-based amplification. Further, these titers drop dramatically with cancer treatment. We also demonstrate the presence of reverse transcriptase and viral RNA in plasma fractions that contain both immature and correctly processed HERV-K (HML-2) Gag and envelope proteins. Finally, using immunoelectron microscopy, we show the presence of HERV-K (HML-2) virus-like particles in the plasma of lymphoma patients. Taken together, these findings demonstrate that elements of the endogenous retrovirus HERV-K (HML-2) can be found in the blood of modern-day humans with certain cancers.

MeSH Terms
Breast Neoplasms/blood,virology Case-Control Studies Contrast Media/pharmacology Endogenous Retroviruses/genetics Humans Lymphoma/blood,virology Microscopy, Immunoelectron RNA, Viral/blood Remission Induction Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Transcription, Genetic Triiodobenzoic Acids/pharmacology
Chemicals
Contrast Media RNA, Viral Triiodobenzoic Acids iodixanol
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Contreras-Galindo Rafael
University of Michigan Medical Center, 5220 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5640, USA.
Kaplan Mark H
Leissner Philippe
Verjat Thibault
Ferlenghi Ilaria
Bagnoli Fabio
Giusti Fabiola
Dosik Michael H
Hayes Daniel F
Gitlin Scott D
Markovitz David M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
1098-5514
Published
2008-10-00
Epub
2008-00-16
Pages
9329-36
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC2546968
Subset
IM
Grants
NIAID NIH HHS · R01 AI062248 · United States
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