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PMID: 16160187 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Conversion of mouse mammary tumor virus to a lymphomagenic virus.

Journal of virology ·Vol. 79 ·No. 19 ·2005-10-00 ·Pages 12592-6

Bhadra S, Lozano MM, Dudley JP

Abstract

Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.

MeSH Terms
Animals Cell Line Enhancer Elements, Genetic Genes, Regulator Humans Jurkat Cells Lymphoma, T-Cell/virology Mammary Neoplasms, Experimental/virology Mammary Tumor Virus, Mouse/genetics,pathogenicity Mice Mice, Inbred BALB C Proviruses/genetics,pathogenicity Retroviridae Infections/virology T-Lymphocytes/virology Terminal Repeat Sequences Transcription, Genetic Transfection Tumor Virus Infections/virology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bhadra Sanchita
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712-0162, USA.
Lozano Mary M
Dudley Jaquelin P
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.79.19.12592-12596.2005
Published
2005-10-00
Pages
12592-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC1211542
Subset
IM
Grants
NCI NIH HHS · P01 CA077760 · United States
NCI NIH HHS · P01 CA77760 · United States
NCI NIH HHS · R01 CA34780 · United States
External Links
PubMed source DOI: 10.1128/JVI.79.19.12592-12596.2005 PMC Full Text View journal details
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