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PMID: 18595683 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Trans-cellular migration: cell-cell contacts get intimate.

Current opinion in cell biology ·Vol. 20 ·No. 5 ·2008-10-00 ·Pages 533-40

Carman CV, Springer TA

Abstract

Trans-cellular migration, the movement of one cell directly through another, seems an unlikely, counterintuitive, and even bizarre process. Trans-cellular migration has been reported for nearly half a century in leukocyte transendothelial migration in vivo, but is not well enough accepted to widely feature in textbook accounts of diapedesis. Recently, the first in vitro and additional in vivo observations of trans-cellular diapedesis have been reported. Mechanisms by which this occurs are just beginning to be elucidated and point to podosome-like protrusive activities in leukocytes and specific fusogenic functions in endothelial cells. Emerging evidence for a quantitatively significant contribution of trans-cellular migration to leukocyte trafficking in increasingly diverse settings suggests that this phenomenon represents an important and physiologic cell biological process.

MeSH Terms
Animals Cell Adhesion/physiology Cell Membrane/metabolism Cell Movement/physiology Cell Surface Extensions/metabolism,ultrastructure Cytoskeleton/metabolism Endothelial Cells/cytology,physiology Humans Leukocytes/cytology,physiology Membrane Fusion/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Carman Christopher V
Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. ccarman@bidmc.harvard.edu
Springer Timothy A
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2008.05.007
Email
ccarman@bidmc.harvard.edu
Published
2008-10-00
Epub
2008-00-01
Pages
533-40
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2811962
Subset
IM
Grants
NCI NIH HHS · R37 CA031798 · United States
NCI NIH HHS · R37 CA031798-29 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2008.05.007 PMC Full Text View journal details
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