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PMID: 4053172 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Extravasation of polymorphonuclear leukocytes from the cerebral microvasculature. Inflammatory response induced by alpha-bungarotoxin.

Cell and tissue research ·Vol. 242 ·No. 2 ·1985-00-00 ·Pages 399-407

Faustmann PM, Dermietzel R

Abstract

Postcapillary venules represent the segment of the microvasculature most vulnerable to inflammatory processes. While there is a considerable body of data on the peripheral vasculature, little is known about the primary events occurring during inflammatory reactions in cerebral blood vessels. We introduce here a model by which the migration of polymorphonuclear leukocytes through the CNS endothelial barrier can be studied. Alpha-bungarotoxin is used as a chemotactic agent and is shown, for the first time, to act by activating the complement cascade. Leukocytes migrate through the endothelium transcellularly. Two modes of migration are described: a direct mode whereby the cells use temporary pores in the vessel wall as portals, and an indirect mode whereby the leukocytes leave the vascular compartment after being enveloped by and incorporated into endothelial cells. The functional implications of these findings lead us to conclude that the direct mode of migration is a causal agent in the massive breakdown of the blood-brain barrier under acute inflammatory conditions.

MeSH Terms
Animals Blood-Brain Barrier Brain/blood supply Bungarotoxins/pharmacology Cats Cell Adhesion Cell Movement Complement Pathway, Alternative Disease Models, Animal Endothelium/pathology Gold Meningitis/chemically induced Microcirculation/physiopathology,ultrastructure Neutrophils/pathology
Chemicals
Bungarotoxins Gold
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Faustmann P M
Dermietzel R
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31 references, click to expand
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00214554
Published
1985-00-00
Pages
399-407
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00214554 View journal details
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