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PMID: 18592367 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders.

Journal of autism and developmental disorders ·Vol. 39 ·No. 1 ·2009-01-00 ·Pages 97-104

Goldberg J, Anderson GM, Zwaigenbaum L, Hall GB, Nahmias C, Thompson A, Szatmari P

Abstract

Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [(18)F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [(18)F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior.

MeSH Terms
Adult Autistic Disorder/diagnostic imaging,genetics Cerebral Cortex/diagnostic imaging Child Female Genetic Predisposition to Disease Humans Male Middle Aged Phenotype Pyrimidinones Radionuclide Imaging Receptors, Serotonin, 5-HT2/analysis Reference Values Serotonin Antagonists
Chemicals
Pyrimidinones Receptors, Serotonin, 5-HT2 Serotonin Antagonists setoperone
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Goldberg Jeremy
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada. goldbej@mcmaster.ca
Anderson George M
Zwaigenbaum Lonnie
Hall Geoffrey B C
Nahmias Claude
Thompson Ann
Szatmari Peter
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Article Info
Journal
Journal of autism and developmental disorders
Abbr.
J Autism Dev Disord
ISSN
0162-3257
DOI
10.1007/s10803-008-0604-4
Email
goldbej@mcmaster.ca
Published
2009-01-00
Epub
2008-00-01
Pages
97-104
Language
English
Region
United States
NLM ID
7904301
Subset
IM
External Links
PubMed source DOI: 10.1007/s10803-008-0604-4 View journal details
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