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PMID: 18574584 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Role of Nox2 in elimination of microorganisms.

Seminars in immunopathology ·Vol. 30 ·No. 3 ·2008-07-00 ·Pages 237-53

Rada B, Hably C, Meczner A, Timár C, Lakatos G, Enyedi P, Ligeti E

Abstract

NADPH oxidase of the phagocytic cells (Nox2) transfers electrons from cytosolic NADPH to molecular oxygen in the extracellular or intraphagosomal space. The produced superoxide anion (O*2) provides the source for formation of all toxic oxygen derivatives, but continuous O*2 generation depends on adequate charge compensation. The vital role of Nox2 in efficient elimination of microorganisms is clearly indicated by human pathology as insufficient activity of the enzyme results in severe, recurrent bacterial infections, the typical symptoms of chronic granulomatous disease. The goals of this contribution are to provide critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions.

MeSH Terms
Animals Cytotoxicity, Immunologic/physiology Humans NADPH Oxidases/immunology,metabolism Phagocytes/enzymology,immunology Superoxides/immunology
Chemicals
Superoxides NADPH Oxidases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Rada Balázs
Laboratory of Host Defenses, Molecular Defenses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Hably Csilla
Meczner András
Timár Csaba
Lakatos Gergely
Enyedi Péter
Ligeti Erzsébet
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Article Info
Journal
Seminars in immunopathology
Abbr.
Semin Immunopathol
ISSN
1863-2297
DOI
10.1007/s00281-008-0126-3
Published
2008-07-00
Epub
2008-00-24
Pages
237-53
Language
English
Region
Germany
NLM ID
101308769
Subset
IM
External Links
PubMed source DOI: 10.1007/s00281-008-0126-3 View journal details
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