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PMID: 185615 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Catabolite modulator factor: a possible mediator of catabolite repression in bacteria.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 10 ·1976-10-00 ·Pages 3476-9

Ullmann A, Tillier F, Monod J

Abstract

Water soluble extracts of Escherichia coli cells have been found to exert an extremely strong repressive effect upon the expression of catabolite sensitive operons. The compound responsible for this activity has been partially purified and proves to be of low molecular weight and heat stable. The effect of this compound, hereafter designated as catabolite modulator factor, is only partially antagonized by adenosine 3':5'-cyclic monophosphate. The possible role of catabolite modulator factor in the physiological regulation of catabolite repression is discussed.

MeSH Terms
Cyclic AMP/antagonists & inhibitors Enzyme Repression Escherichia coli/enzymology,metabolism Galactosidases/biosynthesis Genes, Regulator Hot Temperature Isoelectric Point Lyases/biosynthesis Molecular Weight Mutation Operon Tryptophanase/biosynthesis
Chemicals
Cyclic AMP Galactosidases Lyases Tryptophanase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ullmann A
Tillier F
Monod J
References (11)
11 references, click to expand
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    Proc Natl Acad Sci U S A. 1970 Jul;66(3):773-9 PMID: 4913210
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.10.3476
Published
1976-10-00
Pages
3476-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431138
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.10.3476 PMC Full Text View journal details
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