Catabolite-insensitive revertants of lac promoter mutants.
The maximum rate of expression of the lac operon is severely reduced in lac promoter mutants. Revertants of these mutations which produce higher levels of enzyme were isolated. Some of these revertants had lost sensitivity to catabolite repression and transient repression. The mutations responsible for these losses took place at sites very close to the original promoter mutations. From these results we conclude that the promoter itself is the target site for both catabolite and transient repression of the lac operon.
19 references, click to expand
-
Transient repression of the lac operon.J Bacteriol. 1967 Dec;94(6):2001-11 PMID: 4864411
-
New controlling element in the Lac operon of E. coli.Nature. 1968 Mar 2;217(5131):825-7 PMID: 4867974
-
Evidence for an altered operator specificity: catabolite repression control of the leucine operon in Salmonella typhimurium.J Bacteriol. 1968 Jun;95(6):2263-9 PMID: 4876135
-
Induction and repression of the histidine-degrading enzymes of Bacillus subtilis.J Biol Chem. 1968 Oct 10;243(19):5165-78 PMID: 4971350
-
The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3',5'-adenosine monophosphate.Proc Natl Acad Sci U S A. 1968 Dec;61(4):1336-42 PMID: 4303478
-
Molecular basis of transient repression of beta-galactosidase in Escherichia coli.J Bacteriol. 1969 Feb;97(2):550-6 PMID: 4886283
-
Catabolite sensitive site of the lac operon.Nature. 1969 Mar 15;221(5185):1012-4 PMID: 4886742
-
The nature of mutants in the lac promoter region.J Mol Biol. 1968 Dec;38(3):421-6 PMID: 4887878
-
The step sensitive to catabolite repression and its reversal by 3'-5' cyclic AMP during induced synthesis of beta-galactosidase in E. coli.Biochem Biophys Res Commun. 1969 Jul 7;36(1):84-92 PMID: 4307746
-
Cyclic AMP regulates catabolite and transient repression in E. coli.Nature. 1969 Aug 23;223(5208):810-2 PMID: 4307969
-
The stimulatory effect of cyclic adenosine 3'5'-monophosphate on DNA-directed synthesis of beta-galactosidase in a cell-free system.Proc Natl Acad Sci U S A. 1969 May;63(1):118-22 PMID: 4309055
-
Genetic control of histidine degradation in Salmonella typhimurium, strain LT-2.J Biol Chem. 1969 Oct 10;244(19):5382-91 PMID: 4899017
-
Catabolite repression gene of Escherichia coli.J Bacteriol. 1969 Nov;100(2):809-16 PMID: 4901362
-
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli.Biochem Biophys Res Commun. 1970 Mar 12;38(5):894-901 PMID: 4314384
-
Physiological basis of transient repression of catabolic enzymes in Escherichia coli.J Bacteriol. 1970 May;102(2):411-22 PMID: 4911541
-
THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI.J Mol Biol. 1964 Jan;8:105-27 PMID: 14149954
-
PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEM.Proc Natl Acad Sci U S A. 1964 Oct;52:1067-74 PMID: 14224387
-
Catabolite repression.Cold Spring Harb Symp Quant Biol. 1961;26:249-56 PMID: 14468226
-
ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE.Proc Natl Acad Sci U S A. 1964 Feb;51:266-72 PMID: 14124325
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
