Home LiteratureArticle Details
PMID: 18544962 Published · ppublish English Journal Article Review

Cancer stem cells in breast: current opinion and future challenges.

Pathobiology : journal of immunopathology, molecular and cellular biology ·Vol. 75 ·No. 2 ·2008-00-00 ·Pages 75-84

Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS

Abstract

There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative.

MeSH Terms
Breast Neoplasms/metabolism,pathology,therapy Cell Transformation, Neoplastic/metabolism,pathology Female Humans Neoplastic Stem Cells/metabolism,pathology Receptors, Notch/metabolism Signal Transduction Wnt Proteins/metabolism
Chemicals
Receptors, Notch Wnt Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Charafe-Jauffret Emmanuelle
Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Marseille, France. jauffrete@marseille.fnclcc.fr
Monville Florence
Ginestier Christophe
Dontu Gabriela
Birnbaum Daniel
Wicha Max S
References (73)
73 references, click to expand
  1. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept.
    Cell Prolif. 2003 Oct;36 Suppl 1:73-84 PMID: 14521517
  2. Selective targeting of cancer stem cells: a new concept in cancer therapeutics.
    BioDrugs. 2007;21(5):299-310 PMID: 17896836
  3. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
    Nature. 2006 Dec 7;444(7120):756-60 PMID: 17051156
  4. Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells.
    J Histochem Cytochem. 1986 Jul;34(7):869-81 PMID: 2423579
  5. Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.
    Eur J Biochem. 2000 Jul;267(14):4315-24 PMID: 10880953
  6. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation.
    J Pathol. 2006 Mar;208(4):495-506 PMID: 16429394
  7. Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma.
    J Oral Pathol Med. 2007 Nov;36(10):594-603 PMID: 17944752
  8. CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis.
    Breast Cancer Res. 2006;8(5):R59 PMID: 17062128
  9. Targeting of CD44 eradicates human acute myeloid leukemic stem cells.
    Nat Med. 2006 Oct;12(10):1167-74 PMID: 16998484
  10. Aberrant activation of notch signaling in human breast cancer.
    Cancer Res. 2006 Feb 1;66(3):1517-25 PMID: 16452208
  11. Radiation resistance and stem-like cells in brain tumors.
    Cancer Cell. 2006 Dec;10(6):454-6 PMID: 17157785
  12. Phenotypic characterization of human colorectal cancer stem cells.
    Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 PMID: 17548814
  13. Identification of a basal-like subtype of breast ductal carcinoma in situ.
    Hum Pathol. 2007 Feb;38(2):197-204 PMID: 17234468
  14. Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells.
    Mol Cancer. 2007 Nov 22;6:75 PMID: 18034892
  15. Repeated observation of breast tumor subtypes in independent gene expression data sets.
    Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23 PMID: 12829800
  16. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses.
    Int J Cancer. 2005 Sep 1;116(3):340-50 PMID: 15818618
  17. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity.
    Stem Cells. 2004;22(7):1142-51 PMID: 15579635
  18. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation.
    J Natl Cancer Inst. 2006 Dec 20;98(24):1777-85 PMID: 17179479
  19. Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity.
    Stem Cells. 2006 Apr;24(4):975-85 PMID: 16293577
  20. Tumour stem cells and drug resistance.
    Nat Rev Cancer. 2005 Apr;5(4):275-84 PMID: 15803154
  21. Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective.
    Stem Cell Rev. 2007 Jun;3(2):147-56 PMID: 17873347
  22. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity.
    Blood. 2004 Sep 15;104(6):1648-55 PMID: 15178579
  23. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.
    Curr Biol. 2007 Jan 23;17(2):165-72 PMID: 17196391
  24. Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.
    Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10002-7 PMID: 12890867
  25. Prospective identification of tumorigenic breast cancer cells.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 PMID: 12629218
  26. The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
    J Pathol. 2005 Aug;206(4):451-7 PMID: 15906273
  27. Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis.
    Nat Rev Cancer. 2007 Oct;7(10):791-9 PMID: 17851544
  28. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
    Cancer Res. 2006 Aug 1;66(15):7445-52 PMID: 16885340
  29. Mammary stem cells and breast cancer--role of Notch signalling.
    Stem Cell Rev. 2007 Jun;3(2):169-75 PMID: 17873349
  30. Stem cell origin of death-from-cancer phenotypes of human prostate and breast cancers.
    Stem Cell Rev. 2007 Jan;3(1):79-93 PMID: 17873385
  31. The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.
    Eur Urol. 2008 Mar;53(3):524-31 PMID: 18053634
  32. Aldehyde dehydrogenase gene superfamily: the 2002 update.
    Chem Biol Interact. 2003 Feb 1;143-144:5-22 PMID: 12604184
  33. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.
    Nat Med. 1997 Jul;3(7):730-7 PMID: 9212098
  34. Tumor growth need not be driven by rare cancer stem cells.
    Science. 2007 Jul 20;317(5836):337 PMID: 17641192
  35. Purification and unique properties of mammary epithelial stem cells.
    Nature. 2006 Feb 23;439(7079):993-7 PMID: 16395311
  36. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic.
    Cancer Res. 2005 Jul 15;65(14):6207-19 PMID: 16024622
  37. Characterization of clonogenic multiple myeloma cells.
    Blood. 2004 Mar 15;103(6):2332-6 PMID: 14630803
  38. Molecular definition of breast tumor heterogeneity.
    Cancer Cell. 2007 Mar;11(3):259-73 PMID: 17349583
  39. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):973-8 PMID: 17210912
  40. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
    Cell Stem Cell. 2007 Nov;1(5):555-67 PMID: 18371393
  41. Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo.
    Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3871-6 PMID: 17360445
  42. How to best classify breast cancer: conventional and novel classifications (review).
    Int J Oncol. 2005 Nov;27(5):1307-13 PMID: 16211226
  43. [Towards an integrated cellular and molecular: definition of breast cancers].
    Med Sci (Paris). 2007 Jun-Jul;23(6-7):626-32 PMID: 17631838
  44. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.
    Nature. 2007 Oct 4;449(7162):557-63 PMID: 17914389
  45. Prospective isolation and functional analysis of stem and differentiated cells from the mouse mammary gland.
    Stem Cell Rev. 2007 Jun;3(2):124-36 PMID: 17873345
  46. Identification and expansion of the tumorigenic lung cancer stem cell population.
    Cell Death Differ. 2008 Mar;15(3):504-14 PMID: 18049477
  47. Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis.
    Lab Invest. 2002 Nov;82(11):1525-33 PMID: 12429812
  48. Expression of CD133-1 and CD133-2 in ovarian cancer.
    Int J Gynecol Cancer. 2008 May-Jun;18(3):506-14 PMID: 17868344
  49. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
    Blood. 2007 Jul 1;110(1):278-86 PMID: 17363738
  50. Suppression of human colon cancer tumors in nude mice by siRNA CD44 gene therapy.
    Exp Mol Pathol. 2007 Dec;83(3):332-40 PMID: 17945212
  51. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.
    Cancer Res. 2006 Jun 15;66(12):6063-71 PMID: 16778178
  52. Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers.
    J Cell Mol Med. 2007 Sep-Oct;11(5):981-1011 PMID: 17979879
  53. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype.
    Clin Cancer Res. 2006 Oct 1;12(19):5615-21 PMID: 17020963
  54. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.
    Breast Cancer Res. 2004;6(6):R605-15 PMID: 15535842
  55. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.
    J Natl Cancer Inst. 2007 Apr 18;99(8):616-27 PMID: 17440163
  56. Breast cancer stem cells: a case of mistaken identity?
    Stem Cell Rev. 2007 Jun;3(2):107-9 PMID: 17873341
  57. Basoluminal carcinoma: a new biologically and prognostically distinct entity between basal and luminal breast cancer.
    Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4185-91 PMID: 16857790
  58. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
    Nature. 2006 Aug 17;442(7104):818-22 PMID: 16862118
  59. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.
    Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):781-6 PMID: 14711994
  60. Cancer stem cells: an old idea--a paradigm shift.
    Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 PMID: 16488983
  61. A mouse model of human breast cancer metastasis to human bone.
    Cancer Res. 2005 Jul 15;65(14):6130-8 PMID: 16024614
  62. Stem cells, cancer, and cancer stem cells.
    Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
  63. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
    Genes Dev. 2006 Aug 1;20(15):2096-109 PMID: 16847353
  64. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.
    Cancer Res. 2005 Jul 1;65(13):5506-11 PMID: 15994920
  65. Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival.
    Breast Cancer Res. 2007;9(1):R4 PMID: 17217540
  66. Single nucleotide polymorphisms modify the transporter activity of ABCG2.
    Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72 PMID: 15838659
  67. Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.
    Blood. 2006 Mar 1;107(5):2162-9 PMID: 16269619
  68. Hedgehog signaling in mammary gland development and breast cancer.
    J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):163-73 PMID: 17623270
  69. Prostate cancer and Hedgehog signalling pathway.
    Clin Transl Oncol. 2007 Jul;9(7):420-8 PMID: 17652055
  70. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
    J Cell Biol. 2007 Jan 1;176(1):19-26 PMID: 17190790
  71. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.
    Genes Dev. 2003 May 15;17(10):1253-70 PMID: 12756227
  72. Identification of pancreatic cancer stem cells.
    Cancer Res. 2007 Feb 1;67(3):1030-7 PMID: 17283135
  73. Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
    Nat Cell Biol. 2007 Feb;9(2):201-9 PMID: 17187062
Article Info
Journal
Pathobiology : journal of immunopathology, molecular and cellular biology
Abbr.
Pathobiology
ISSN
1423-0291
DOI
10.1159/000123845
Email
jauffrete@marseille.fnclcc.fr
Published
2008-00-00
Epub
2008-00-10
Pages
75-84
Language
English
Region
Switzerland
NLM ID
9007504
PMCID
PMC2789397
Subset
IM
Grants
NCI NIH HHS · R01 CA129765 · United States
NCI NIH HHS · R01 CA129765-02 · United States
External Links
PubMed source DOI: 10.1159/000123845 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2