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PMID: 18521075 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Advances in bacterial promoter recognition and its control by factors that do not bind DNA.

Nature reviews. Microbiology ·Vol. 6 ·No. 7 ·2008-07-00 ·Pages 507-19

Haugen SP, Ross W, Gourse RL

Abstract

Early work identified two promoter regions, the -10 and -35 elements, that interact sequence specifically with bacterial RNA polymerase (RNAP). However, we now know that several additional promoter elements contact RNAP and influence transcription initiation. Furthermore, our picture of promoter control has evolved beyond one in which regulation results solely from activators and repressors that bind to DNA sequences near the RNAP binding site: many important transcription factors bind directly to RNAP without binding to DNA. These factors can target promoters by affecting specific kinetic steps on the pathway to open complex formation, thereby regulating RNA output from specific promoters.

MeSH Terms
Bacterial Proteins/metabolism DNA/metabolism DNA-Directed RNA Polymerases/metabolism Gene Expression Regulation, Bacterial Promoter Regions, Genetic/genetics Transcription Factors/metabolism Transcription, Genetic
Chemicals
Bacterial Proteins Transcription Factors DNA DNA-Directed RNA Polymerases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Haugen Shanil P
Department of Bacteriology, University of Wisconsin- Madison, 1550 Linden Drive, Madison, Wisconsin 53706, USA.
Ross Wilma
Gourse Richard L
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro1912
Published
2008-07-00
Epub
2008-00-03
Pages
507-19
Language
English
Region
England
NLM ID
101190261
PMCID
PMC3700611
Subset
IM
Grants
NIGMS NIH HHS · R37 GM037048 · United States
NIGMS NIH HHS · R37 GM37048 · United States
External Links
PubMed source DOI: 10.1038/nrmicro1912 PMC Full Text View journal details
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