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PMID: 18506144 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness.

British journal of cancer ·Vol. 98 ·No. 12 ·2008-06-17 ·Pages 1886-93

Le NH, Franken P, Fodde R

Abstract

Sporadic cases of colorectal cancer are primarily initiated by gene mutations in members of the canonical Wnt pathway, ultimately resulting in beta-catenin stabilisation. Nevertheless, cells displaying nuclear beta-catenin accumulation are nonrandomly distributed throughout the tumour mass and preferentially localise along the invasive front where parenchymal cells are in direct contact with the stromal microenvironment. Here, we discuss the putative role played by stromal cell types in regulating beta-catenin intracellular accumulation in a paracrine fashion. As such, the tumour microenvironment is likely to maintain the cancer stem cell phenotype in a subset of cells, thus mediating invasion and metastasis.

MeSH Terms
Adipocytes/cytology Colorectal Neoplasms/immunology,metabolism,pathology Humans Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Stem Cells/metabolism,pathology Stromal Cells/metabolism,pathology beta Catenin/metabolism
Chemicals
beta Catenin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Le N H
Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Erasmus MC, Rotterdam, The Netherlands.
Franken P
Fodde R
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
1532-1827
DOI
10.1038/sj.bjc.6604401
Published
2008-06-17
Epub
2008-00-27
Pages
1886-93
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2441948
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6604401 PMC Full Text View journal details
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