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PMID: 18467654 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation.

Journal of leukocyte biology ·Vol. 84 ·No. 3 ·2008-09-00 ·Pages 587-94

Cardona AE, Li M, Liu L, Savarin C, Ransohoff RM

Abstract

Actions of chemokines and the interaction with specific receptors go beyond their original, defined role of recruiting leukocytes to inflamed tissues. Chemokine receptor expression in peripheral elements and resident cells of the central nervous system (CNS) represents a relevant communication system during neuroinflammatory conditions. The following examples are described in this review: Chemokine receptors play important homeostatic properties by regulating levels of specific ligands in blood and tissues during healthy and pathological conditions; chemokines and their receptors are clearly involved in leukocyte extravasation and recruitment to the CNS, and current studies are directed toward understanding the interaction between chemokine receptors and matrix metalloproteinases in the process of blood brain barrier breakdown. We also propose novel functions of chemokine receptors during demyelination/remyelination, and developmental processes.

MeSH Terms
Animals Blood-Brain Barrier Brain/metabolism Chemokines/physiology Chemotaxis/physiology Encephalomyelitis, Autoimmune, Experimental/metabolism Humans Receptors, Chemokine/metabolism
Chemicals
Chemokines Receptors, Chemokine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Cardona Astrid E
Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ransohr@ccf.org
Li Meizhang
Liu Liping
Savarin Carine
Ransohoff Richard M
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Article Info
Journal
Journal of leukocyte biology
Abbr.
J Leukoc Biol
ISSN
0741-5400
DOI
10.1189/jlb.1107763
Email
ransohr@ccf.org
Published
2008-09-00
Epub
2008-00-08
Pages
587-94
Language
English
Region
United States
NLM ID
8405628
PMCID
PMC2516908
Subset
IM
Grants
NINDS NIH HHS · P01 NS018146 · United States
NINDS NIH HHS · R01 NS032151 · United States
NINDS NIH HHS · NS018146-26 · United States
NINDS NIH HHS · NS32151 · United States
External Links
PubMed source DOI: 10.1189/jlb.1107763 PMC Full Text View journal details
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