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PMID: 18446160 Published · ppublish English Journal Article Review

A technicolour approach to the connectome.

Nature reviews. Neuroscience ·Vol. 9 ·No. 6 ·2008-06-00 ·Pages 417-22

Lichtman JW, Livet J, Sanes JR

Abstract

A central aim of neuroscience is to map neural circuits, in order to learn how they account for mental activities and behaviours and how alterations in them lead to neurological and psychiatric disorders. However, the methods that are currently available for visualizing circuits have severe limitations that make it extremely difficult to extract precise wiring diagrams from histological images. Here we review recent advances in this area, along with some of the opportunities that these advances present and the obstacles that remain.

MeSH Terms
Animals Animals, Genetically Modified Brain/physiology,ultrastructure Brain Mapping/methods Coloring Agents Humans Luminescent Proteins/genetics Microscopy, Electron Neural Pathways/physiology,ultrastructure Neurons/physiology Neurosciences/methods,trends Staining and Labeling Transgenes
Chemicals
Coloring Agents Luminescent Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lichtman Jeff W
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA. jeff@mcb.harvard.edu
Livet Jean
Sanes Joshua R
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn2391
Email
jeff@mcb.harvard.edu
Published
2008-06-00
Epub
2008-00-30
Pages
417-22
Language
English
Region
England
NLM ID
100962781
PMCID
PMC2577038
Subset
IM
Grants
NINDS NIH HHS · R01 NS020364 · United States
NINDS NIH HHS · R01 NS020364-26 · United States
External Links
PubMed source DOI: 10.1038/nrn2391 PMC Full Text View journal details
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