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PMID: 18434574 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Proteome of human minor salivary gland secretion.

Journal of dental research ·Vol. 87 ·No. 5 ·2008-05-00 ·Pages 445-50

Siqueira WL, Salih E, Wan DL, Helmerhorst EJ, Oppenheim FG

Abstract

Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might hypothesize that the proteome of minor gland secretions may show significantly different characteristics when compared with the proteomes of parotid or submandibular/sublingual secretions. To test this hypothesis, we conducted the first exploration into the proteome of minor salivary gland secretion. Minor gland secretion was obtained from healthy volunteers, and its components were subjected to liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry. This led to the identification of 56 proteins, 12 of which had never been identified in any salivary secretion. The unique characteristics of the minor salivary gland secretion proteome are related to the types as well as the numbers of components present. The differences between salivary proteomes may be important with respect to specific oral functions.

MeSH Terms
Adult Female Humans Male Proteome/analysis Proteomics/methods Reference Values Salivary Glands, Minor/metabolism Salivary Proteins and Peptides/analysis,classification,metabolism
Chemicals
Proteome Salivary Proteins and Peptides
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Siqueira W L
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, CABR, Suite W-201, Boston, MA 02118, USA.
Salih E
Wan D L
Helmerhorst E J
Oppenheim F G
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Article Info
Journal
Journal of dental research
Abbr.
J Dent Res
ISSN
0022-0345
DOI
10.1177/154405910808700508
Published
2008-05-00
Pages
445-50
Language
English
Region
United States
NLM ID
0354343
PMCID
PMC2857507
Subset
IM
Grants
NIDCR NIH HHS · U01 DE017788 · United States
NIDCR NIH HHS · DE05672 · United States
NIDCR NIH HHS · DE17788 · United States
NIDCR NIH HHS · F31 DE005672 · United States
NIDCR NIH HHS · DE18132 · United States
NIDCR NIH HHS · R21 DE018132 · United States
NIDCR NIH HHS · R01 DE005672 · United States
NIDCR NIH HHS · R01 DE007652-20 · United States
NIDCR NIH HHS · R37 DE005672 · United States
NIDCR NIH HHS · R01 DE007652 · United States
NIDCR NIH HHS · DE07652 · United States
NIDCR NIH HHS · R01 DE005672-27 · United States
External Links
PubMed source DOI: 10.1177/154405910808700508 PMC Full Text View journal details
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