Circadian rhythms in human salivary flow rate and composition.

The Journal of physiology ·Vol. 220 ·No. 3 ·1972-02-00 ·Pages 529-45

Dawes C

Abstract

1. Unstimulated whole saliva and parotid saliva stimulated at a constant flow rate of 1.0 ml./min were collected from eight subjects at about 07.00, 11.00, 14.00, 17.00 and 22.00 hr and oral temperature was recorded several times daily for time spans of between 4 and 26 days. A least-squares cosine wave was fitted to the data to test for the presence and characteristics of circadian rhythms.2. Estimates of mean level, amplitude, acrophase and period were obtained for different components and the results were subjected to cosinor analysis.3. Unstimulated whole saliva showed significant circadian rhythms in flow rate and in the concentrations of sodium and chloride but not in protein, potassium, calcium, phosphate or urea.4. Stimulated parotid saliva showed significant circadian rhythms in the concentrations of protein, sodium, potassium, calcium and chloride but not in phosphate or urea5. Oral temperature showed a circadian rhythm which, like the salivary rhythms, was of a 24.0 hr periodicity.

MeSH Terms

Adult Body Temperature Calcium/analysis Chlorides/analysis Circadian Rhythm Colorimetry Female Humans Male Parotid Gland/metabolism Phosphates/analysis Potassium/analysis Proteins/analysis Saliva/analysis Salivation Secretory Rate Sodium/analysis Spectrum Analysis Urea/analysis

Chemicals

Chlorides Phosphates Proteins Urea Sodium Potassium Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dawes C

References (28)

28 references, click to expand

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Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1972.sp009721

Published

1972-02-00

Pages

529-45

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1331668

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1972.sp009721 PMC Full Text View journal details

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