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PMID: 18421579 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.

Apoptosis : an international journal on programmed cell death ·Vol. 13 ·No. 6 ·2008-06-00 ·Pages 733-47

Taylor JM, Nicot C

Abstract

A universal cellular defense mechanism against viral invasion is the elimination of infected cells through apoptotic cell death. To counteract host defenses many viruses have evolved complex apoptosis evasion strategies. The oncogenic human retrovirus HTLV-1 is the etiological agent of adult-T-cell leukemia/lymphoma (ATLL) and the neurodegenerative disease known as HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The poor prognosis in HTLV-1-induced ATLL is linked to the resistance of neoplastic T cells against conventional therapies and the immuno-compromised state of patients. Nevertheless, several studies have shown that the apoptotic pathway is largely intact and can be reactivated in ATLL tumor cells to induce specific killing. A better understanding of the molecular mechanisms employed by HTLV-1 to counteract cellular death pathways remains an important challenge for future therapies and the treatment of HTLV-1-associated diseases.

MeSH Terms
Apoptosis/drug effects,physiology Cell Transformation, Viral/physiology Gene Products, tax/physiology Human T-lymphotropic virus 1/drug effects,physiology Humans I-kappa B Kinase/physiology Janus Kinases/physiology Leukemia-Lymphoma, Adult T-Cell/drug therapy,virology NF-kappa B/antagonists & inhibitors,physiology Paraparesis, Tropical Spastic/drug therapy,virology Proto-Oncogene Proteins c-akt/physiology Receptors, Interleukin-2/physiology Retroviridae Proteins/physiology STAT Transcription Factors/physiology Tretinoin/pharmacology Tumor Suppressor Protein p53/physiology Viral Regulatory and Accessory Proteins/physiology
Chemicals
Gene Products, tax NF-kappa B Receptors, Interleukin-2 Retroviridae Proteins STAT Transcription Factors Tumor Suppressor Protein p53 Viral Regulatory and Accessory Proteins p12I protein, Human T-lymphotropic virus 1 rof protein, Human T-lymphotropic virus 1 tof protein, Human T-lymphotropic virus 1 Tretinoin Janus Kinases Proto-Oncogene Proteins c-akt I-kappa B Kinase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Taylor John M
Department of Microbiology, Immunology, and Molecular Genetics, University of Kansas Medical Center, 3025 Wahl Hall West, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Nicot Christophe
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Article Info
Journal
Apoptosis : an international journal on programmed cell death
Abbr.
Apoptosis
ISSN
1573-675X
DOI
10.1007/s10495-008-0208-7
Published
2008-06-00
Pages
733-47
Language
English
Region
Netherlands
NLM ID
9712129
PMCID
PMC2633601
Subset
IM
Grants
NCI NIH HHS · R01 CA115398-01A2 · United States
NCI NIH HHS · R01 CA115398 · United States
NCI NIH HHS · CA106258 · United States
NCI NIH HHS · R01 CA106258-05 · United States
NCI NIH HHS · CA115398 · United States
NCI NIH HHS · R01 CA106258 · United States
External Links
PubMed source DOI: 10.1007/s10495-008-0208-7 PMC Full Text View journal details
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