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PMID: 18392144 Published · epublish English Journal Article Review

Expression and function of micro-RNAs in immune cells during normal or disease state.

International journal of medical sciences ·Vol. 5 ·No. 2 ·2008-04-03 ·Pages 73-9

Tili E, Michaille JJ, Calin GA

Abstract

Micro-RNAs (miRNAs) are 19-24 nucleotide long non-coding RNAs that posttranscriptionally modulate gene expression. They are found in almost all species: viruses, plants, nematodes, fly, fish, mouse, human, and are implicated in a wide array of cellular and developmental processes. Microarray-based miRNA profiling brought to the discovery of miRNAs specific to different hematopoietic lineages. Furthermore, the functional assays performed in tissue cultures to discover miRNAs involved in immune responses in combination with the reports of miRNA-transgenic or miRNA -knockout mouse models has helped elucidating the miRNA roles in the development and function of immune system. Abnormal patterns of hematopoietic-specific miRNAs have been found in different types of cancer and miRNA based gene therapy is being considered as a potential technology of choice in immunological disorders and cancer. The purpose of this review is to discuss recent findings related with the expression and function of miRNAs in hematopoietic lineages.

Keywords
Acquired immune response Cancer Cytokines Drug discovery Hematopoietic lineage Innate immune response TNF-α.
MeSH Terms
Animals Cell Differentiation Cell Lineage Genetic Therapy Hematopoietic System/metabolism Humans Immune System/metabolism MicroRNAs/biosynthesis,metabolism Neoplasms/metabolism
Chemicals
MicroRNAs
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tili Esmerina
Ohio State University, Department of Molecular Virology, Immunology, Medical Genetics, Comprehensive Cancer Center, 385L Wiseman Hall, 400 W. 12th Ave., Columbus, OH 43210, USA.
Michaille Jean-Jacques
Calin George Adrian
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Article Info
Journal
International journal of medical sciences
Abbr.
Int J Med Sci
ISSN
1449-1907
DOI
10.7150/ijms.5.73
Published
2008-04-03
Epub
2008-00-03
Pages
73-9
Language
English
Region
Australia
NLM ID
101213954
PMCID
PMC2288788
Subset
IM
External Links
PubMed source DOI: 10.7150/ijms.5.73 PMC Full Text View journal details
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