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PMID: 18325257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

High rate of mobilization for blaCTX-Ms.

Emerging infectious diseases ·Vol. 14 ·No. 3 ·2008-03-00 ·Pages 423-8

Barlow M, Reik RA, Jacobs SD, Medina M, Meyer MP, McGowan JE, Tenover FC

Abstract

We constructed a phylogenetic analysis of class A beta-lactamases and found that the blaCTX-Ms have been mobilized to plasmids approximately 10 times more frequently than other class A beta-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects,enzymology,genetics DNA, Bacterial/genetics Drug Resistance, Multiple, Bacterial/genetics Evolution, Molecular Gene Transfer, Horizontal Genetic Variation Phylogeny Plasmids/genetics,metabolism Protein Transport beta-Lactamases/classification,metabolism
Chemicals
Anti-Bacterial Agents DNA, Bacterial beta-Lactamases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Barlow Miriam
University of California, Merced, California 95344, USA. mbarlow@ucmerced.edu
Reik Rebecca A
Jacobs Stephen D
Medina Mónica
Meyer Matthew P
McGowan John E
Tenover Fred C
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Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6059
DOI
10.3201/eid1403.070405
Email
mbarlow@ucmerced.edu
Published
2008-03-00
Pages
423-8
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC2570810
Subset
IM
External Links
PubMed source DOI: 10.3201/eid1403.070405 PMC Full Text View journal details
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