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PMID: 12435721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases.

Antimicrobial agents and chemotherapy ·Vol. 46 ·No. 12 ·2002-12-00 ·Pages 4038-40

Poirel L, Kämpfer P, Nordmann P

Abstract

A chromosome-encoded beta-lactamase gene, cloned and expressed in Escherichia coli from Kluyvera georgiana reference strain CUETM 4246-74 (DSM 9408), encoded the extended-spectrum beta-lactamase KLUG-1, which shared 99% amino acid identity with the plasmid-mediated beta-lactamase CTX-M-8. This work provides further evidence that Kluyvera spp. may be the progenitor(s) of CTX-M-type beta-lactamases.

MeSH Terms
Amino Acid Sequence Anti-Bacterial Agents/pharmacology Bacterial Proteins Cloning, Molecular Enterobacteriaceae/drug effects,genetics Escherichia coli/genetics Microbial Sensitivity Tests Molecular Sequence Data Sequence Homology, Amino Acid beta-Lactamases/drug effects,genetics
Chemicals
Anti-Bacterial Agents Bacterial Proteins blaCTX-M-8 protein, Citrobacter amalonaticus beta-Lactamases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Poirel Laurent
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
Kämpfer Peter
Nordmann Patrice
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19 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.46.12.4038-4040.2002
Published
2002-12-00
Pages
4038-40
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC132763
Subset
IM
Databases
GENBANK
AF501233
External Links
PubMed source DOI: 10.1128/AAC.46.12.4038-4040.2002 PMC Full Text View journal details
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